Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004940)
Formula	Glucuronidation
	Reactant	Thalidomide arene oxide	Product	5-Hydroxythalidomide
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004939	Thalidomide	Thalidomide arene oxide	Oxidation - Epoxidation	Thalidomide	[1], [2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004934	Thalidomide	5-Hydroxythalidomide	Oxidation - Aromatic hydroxylation	Thalidomide	[1], [2]

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2	Thalidomide metabolism and hydrolysis: mechanisms and implications

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.