Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004939)
Formula
CYP1A1 ...
SVG example
Epoxidation
Reactant Thalidomide Product Thalidomide arene oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004921 Thalidomide 2-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004943 Thalidomide 4-hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [3]
MR004914 Thalidomide 4-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004934 Thalidomide 5-Hydroxythalidomide Oxidation - Aromatic hydroxylation Thalidomide [4], [2]
MR004925 Thalidomide Alpha-(o-carboxybenzamido)glutarimide Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004937 Thalidomide Cis, trans-5'-Hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [4], [2]
MR004942 Thalidomide N-Hydroxythalidomide Oxidation - Hydrolyzation Thalidomide [3]
MR004941 Thalidomide Thalidomide-5-O-glucuronide Oxidation - Hydrolyzationn Thalidomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004940 Thalidomide arene oxide 5-Hydroxythalidomide Conjugation - Glucuronidation Thalidomide [4]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications
3 Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients. J Biochem Mol Toxicol. 2000;14(3):140-7.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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