Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005140)
Formula
SVG example
N-dealkylation
Reactant Hydroxychloroquine sulfate Product Desethylchloroquine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005141 Hydroxychloroquine sulfate Desethylhydroxychloroquine Oxidation - N-dealkylation Hydroxychloroquine sulfate [1], [2], [3]
MR005142 Hydroxychloroquine sulfate Bidesethylchloroquine Oxidation - N-dealkylation Hydroxychloroquine sulfate [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012185 Hydroxychloroquine Monodesethylchloroquine Unclear - Unclear Hydroxychloroquine [4], [3]
References
1 Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother. 2009 Apr;53(4):1468-75.
2 Hydroxychloroquine: a physiologically-based pharmacokinetic model in the context of cancer-related autophagy modulation. J Pharmacol Exp Ther. 2018 Jun;365(3):447-459.
3 Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters Curr Drug Metab. 2020;21(14):1127-1135. doi: 10.2174/1389200221999201208211537.
4 The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects

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