| General Information of This Metabolic Reaction (MR) (ID:
MR005189) |
| Formula |
|
| Reactant |
Proguanil |
Product |
Cycloguanil |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME Info
|
|
Metabolic Type
|
Other reaction
-
Cyclisation
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Reactant of This MR |
|
Other MR(s) That Metabolize The Reactant of This MR
|
|
|
| References |
| 1 |
Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry
|
| 2 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy
|
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