Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR005245)
Formula	N-demethylation
	Reactant	Roxithromycin		Product	N-di-demethyl roxithromycin
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - N-demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005244	Roxithromycin	Descladinose roxithromycin	Unclear	Roxithromycin	[1]
MR005246	Roxithromycin	N-mono roxithromycin	Oxidation - N-demethylation	Roxithromycin	[2], [1]
MR005239	Roxithromycin	Roxithromycin metabolite M2	Oxidation - O-dealkylation	Roxithromycin	[2], [1]
MR005242	Roxithromycin	Roxithromycin metabolite M4	Oxidation - O-demethylation	Roxithromycin	[1]

References
1	Identification of the metabolites of roxithromycin in humans
2	Metabolism of roxithromycin in phenobarbital-treated rat liver microsomes

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