Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005262)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Silymarin Product 20-O-beta-D-Glu
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005261 Silymarin O-demethylated-silybin Oxidation - O-dealkylation Silymarin [1], [2]
MR005263 Silymarin Silybin 7-glucoside Conjugation - Glucuronidation Silymarin [3], [2]
References
1 Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes
2 Metabolism, Transport and Drug-Drug Interactions of Silymarin
3 Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases

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