Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005263)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Silymarin Product Silybin 7-glucoside
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005262 Silymarin 20-O-beta-D-Glu Conjugation - Glucuronidation Silymarin [1], [2]
MR005261 Silymarin O-demethylated-silybin Oxidation - O-dealkylation Silymarin [3], [2]
References
1 Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
2 Metabolism, Transport and Drug-Drug Interactions of Silymarin
3 Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes

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