Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005261)
Formula
SVG example
O-dealkylation
Reactant Silymarin Product O-demethylated-silybin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005262 Silymarin 20-O-beta-D-Glu Conjugation - Glucuronidation Silymarin [1], [2]
MR005263 Silymarin Silybin 7-glucoside Conjugation - Glucuronidation Silymarin [1], [2]
References
1 Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
2 Metabolism, Transport and Drug-Drug Interactions of Silymarin

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