Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005274)
Formula
SVG example
Hydrolysis
Reactant 5-FUH2 Product FUPA
Reactant Info Product Info
Metabolic Enzyme Dihydropyrimidinase-related protein 2 (DPYSL2) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001055 5-fluorouracil 5,6-Dihydro-5-fluorouracil Reduction - Reduction Floxuridine [1], [2]
MR005273 Fluorouracil 5-FUH2 Oxidation - Dehydrogenation Tegafur-uracil [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001056 5,6-Dihydro-5-fluorouracil Fluoro-beta-ureidopropionate Hydrolysis - Hydrolysis Floxuridine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002525 FUH2 FUPA Hydrolysis - Hydrolysis Capecitabine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005275 FUPA FBAL Hydrolysis - Hydrolysis Tegafur-uracil [3]
MR005276 FUPA Urea Hydrolysis - Hydrolysis Tegafur-uracil [3]
MR002526 FUPA FBAL Hydrolysis - Amide Hydrolysis Capecitabine [4]
References
1 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
2 The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, -fluoro--ureidopropionate, -fluoro--alanine using LC-MS J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045.
3 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
4 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

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