Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005276)
Formula
SVG example
Hydrolysis
Reactant FUPA Product Urea
Reactant Info Product Info
Metabolic Enzyme Beta-Ureidopropionase (BUP-1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005274 5-FUH2 FUPA Hydrolysis - Hydrolysis Tegafur-uracil [1]
MR002525 FUH2 FUPA Hydrolysis - Hydrolysis Capecitabine [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005275 FUPA FBAL Hydrolysis - Hydrolysis Tegafur-uracil [1]
MR002526 FUPA FBAL Hydrolysis - Amide Hydrolysis Capecitabine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003078 Agmatine Urea Unclear Agmatine [3]
MR000203 Ammonia Urea Unclear Ammonia [4]
MR004282 [1-(2-aminoimidazol-1-yl)-3-methoxypropan-2-ol] (AIM) Urea Hydrolysis - Hydrolyzation Misonidazole [5]
MR003075 Gamma-guanidinobutyrate Urea Unclear Agmatine [3], [6]
MR004034 Allantoic acid Urea Unclear Xanthine [7]
References
1 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
2 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
3 Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine Amino Acids. 2004 Feb;26(1):3-8. doi: 10.1007/s00726-003-0030-z.
4 Ammonia Transporters and Their Role in Acid-Base Balance Physiol Rev. 2017 Apr;97(2):465-494. doi: 10.1152/physrev.00011.2016.
5 Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells
6 A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria. Nat Commun. 2021 Aug 26;12(1):5150. doi: 10.1038/s41467-021-25369-x.
7 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism

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