Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005416)
Formula
SVG example
Oxidationn ring opening
Reactant ABL001 Product Asciminib metabolite M37
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn ring opening
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011635 ABL001 ABL001 Metabolite M45 Unclear - Unclear ABL001 [1]
MR011633 ABL001 ABL001 Metabolite M8 Hydrolysis - Hydrolysis ABL001 [1]
MR005419 ABL001 Asciminib metabolite M10 Oxidation - O-dealkylation ABL001 [1]
MR005426 ABL001 Asciminib metabolite M27.5 Conjugation - Glucuronidation ABL001 [1]
MR005424 ABL001 Asciminib metabolite M29.5 Oxidation - Oxidationn ring opening ABL001 [1]
MR005421 ABL001 Asciminib metabolite M30.5 Conjugation - Glucuronidation ABL001 [1]
MR005425 ABL001 Asciminib metabolite M39 Oxidation - Oxidationn ring opening ABL001 [1]
MR005423 ABL001 Asciminib metabolite M44 Oxidation - Oxidationn ABL001 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005417 Asciminib metabolite M37 Asciminib metabolite M43.3 Unclear ABL001 [1]
References
1 Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects

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