Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005482)
Formula	CYP3A4 Hydrolyzationn
	Reactant	Finerenone M4 Metabolite	Product	Finerenone M5 Metabolite
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info
Metabolic Type	Oxidation - Hydrolyzationn

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005481	Finerenone	Finerenone M4 Metabolite	Oxidation - Epoxidation; hydroxylation	Finerenone	[1], [2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005483	Finerenone M5 Metabolite	Finerenone M8 Metabolite	Oxidation - Oxidationn	Finerenone	[3]

References
1	Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
2	Results From Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3
3	DrugBank(Pharmacology-Metabolism):Finerenone

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.