Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005551)
Formula
SVG example
Reduction
Reactant Nifurtimox Product Nifurtimox M1
Reactant Info Product Info
Metabolic Enzyme Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005557 Nifurtimox Nifurtimox M10 Reduction - Reduction Nifurtimox [1]
MR005541 Nifurtimox Nifurtimox M11 Oxidation - Oxidationn Nifurtimox [1]
MR005542 Nifurtimox Nifurtimox M12 Oxidation - Oxidationn Nifurtimox [1]
MR005553 Nifurtimox Nifurtimox M13 Reduction - Reduction Nifurtimox [1]
MR005554 Nifurtimox Nifurtimox M14 Reduction - Reduction Nifurtimox [1]
MR005544 Nifurtimox Nifurtimox M15 Other reaction - Nucleophilic reaction Nifurtimox [1]
MR005543 Nifurtimox Nifurtimox M16 Oxidation - Oxidationn Nifurtimox [1]
MR005552 Nifurtimox Nifurtimox M17 Reduction - Reduction Nifurtimox [1], [2]
MR005545 Nifurtimox Nifurtimox M18 Other reaction - Nucleophilic reaction Nifurtimox [1]
MR005550 Nifurtimox Nifurtimox M2 Reduction - Reduction Nifurtimox [1]
MR005549 Nifurtimox Nifurtimox M3 Reduction - Reduction Nifurtimox [1]
MR005539 Nifurtimox Nifurtimox M4 Other reaction - Nucleophilic reaction Nifurtimox [1]
MR005546 Nifurtimox Nifurtimox M5 Other reaction - Nucleophilic reaction Nifurtimox [1]
MR005547 Nifurtimox Nifurtimox M6 Reduction - Reduction Nifurtimox [1]
MR005555 Nifurtimox Nifurtimox M7 Reduction - Reduction Nifurtimox [1]
MR005556 Nifurtimox Nifurtimox M8 Reduction - Reduction Nifurtimox [1]
MR005548 Nifurtimox Nifurtimox M9 Reduction - Reduction Nifurtimox [1]
MR005558 Nifurtimox Nitrite Unclear Nifurtimox [3]
References
1 Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox
2 Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites
3 Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

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