Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005578)
Formula
SVG example
O-dealkylation
Reactant Pacritinib Product Pacritinib M2 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005577 Pacritinib Pacritinib M1 metabolite Oxidation - Oxidationn Pacritinib [1]
MR005579 Pacritinib Pacritinib M3 metabolite Other reaction - Oxidation Pacritinib [1]
MR005580 Pacritinib Pacritinib M4 metabolite Reduction - Reduction Pacritinib [1]
References
1 Metabolism and Disposition of Pacritinib (SB1518), an Orally Active Janus Kinase 2 Inhibitor in Preclinical Species and Humans

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