Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR005580)
Formula	CYP3A4 Reduction
	Reactant	Pacritinib		Product	Pacritinib M4 metabolite
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
Metabolic Type	Reduction - Reduction

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005577	Pacritinib	Pacritinib M1 metabolite	Oxidation - Oxidationn	Pacritinib	[1]
MR005578	Pacritinib	Pacritinib M2 metabolite	Oxidation - O-dealkylation	Pacritinib	[1]
MR005579	Pacritinib	Pacritinib M3 metabolite	Other reaction - Oxidation	Pacritinib	[1]

References
1	Metabolism and Disposition of Pacritinib (SB1518), an Orally Active Janus Kinase 2 Inhibitor in Preclinical Species and Humans

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