Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005598)
Formula
SVG example
Reactant Phenylbutenoyl-CoA Product Beta-Hydroxyphenylbutyryl-CoA
Reactant Info Product Info
Metabolic Enzyme Enoyl-CoA hydratase (ECHS1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013767 Phenybutyryl-CoA Phenylbutenoyl-CoA Unclear - Unclear phenylbutyrate [1]
MR005597 Phenylbutyryl-CoA Phenylbutenoyl-CoA Unclear Sodium phenylbutyrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005599 Beta-Hydroxyphenylbutyryl-CoA Beta-Ketophenylbutyryl-CoA Unclear Sodium phenylbutyrate [2]
MR013769 Beta-Hydroxyphenylbutyryl-CoA Beta-Ketophenylbutyryl-CoA Unclear - Unclear phenylbutyrate [1]
References
1 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
2 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate

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