Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005628)
Formula Reactant Tepotinib Product Tepotinib M506 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005632 Tepotinib TEPCN518 Unclear Tepotinib [1]
MR005631 Tepotinib TEPCN520 Unclear Tepotinib [1]
MR005633 Tepotinib TEPCN534a Unclear Tepotinib [1]
MR005634 Tepotinib TEPCN534b Unclear Tepotinib [1]
MR005629 Tepotinib Tepotinib M478 metabolite Oxidation - N-demethylation Tepotinib [2]
MR005630 Tepotinib Tepotinib M508 metabolite Oxidation - N-oxidation Tepotinib [2]
References
1 Identification of Iminium Intermediates Generation in the Metabolism of Tepotinib Using LC-MS/MS: In Silico and Practical Approaches to Bioactivation Pathway Elucidation
2 Open-label, single-center, phase I trial to investigate the mass balance and absolute bioavailability of the highly selective oral MET inhibitor tepotinib in healthy volunteers

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