Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005671)
Formula
CYP2D6 ...
SVG example
Hydrolyzationn
Reactant Vortioxetine hydrobromide Product LU-AA39835
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005668 Vortioxetine hydrobromide Vortioxetine Metabolite 1 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
MR005673 Vortioxetine hydrobromide Vortioxetine Metabolite 2 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
MR005674 Vortioxetine hydrobromide Vortioxetine Metabolite 4a Oxidation - Oxidationn Vortioxetine hydrobromide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005672 LU-AA39835 LU-AA34443 Glucuronide Metabolite Conjugation - Glucuronidation Vortioxetine hydrobromide [1], [2]
References
1 Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65.
2 Vortioxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2018 Jun;57(6):673-686.

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