Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005674)
Formula
CYP3A5 ...
SVG example
Oxidationn
Reactant Vortioxetine hydrobromide Product Vortioxetine Metabolite 4a
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005671 Vortioxetine hydrobromide LU-AA39835 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
MR005668 Vortioxetine hydrobromide Vortioxetine Metabolite 1 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
MR005673 Vortioxetine hydrobromide Vortioxetine Metabolite 2 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
References
1 Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65.
2 Vortioxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2018 Jun;57(6):673-686.

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