Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005683)
Formula
SVG example
N-oxidation
Reactant Zileuton Product Zolmitriptan N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013296 Zileuton Dehydroxyzyleuton Reduction - N-dehydroxylation Zileuton [1], [2]
MR013299 Zileuton Hydroxyzileuton Oxidation - Hydrolyzationn Zileuton [1], [2]
MR013301 Zileuton Zileuton O-glucuronide metabolite Conjugation - N-hydroxy glucuronidation Zileuton [1], [2]
MR013300 Zileuton Zileuton sulfoxide Oxidation - Sulfoxidation Zileuton [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.

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