Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013300)
Formula
SVG example
Sulfoxidation
Reactant Zileuton Product Zileuton sulfoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Sulfoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013296 Zileuton Dehydroxyzyleuton Reduction - N-dehydroxylation Zileuton [1], [2]
MR013299 Zileuton Hydroxyzileuton Oxidation - Hydrolyzationn Zileuton [1], [2]
MR013301 Zileuton Zileuton O-glucuronide metabolite Conjugation - N-hydroxy glucuronidation Zileuton [1], [2]
MR005683 Zileuton Zolmitriptan N-oxide Oxidation - N-oxidation Zolmitriptan [3], [4]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Indolealkylamines: biotransformations and potential drug-drug interactions
4 Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica. 1999 Aug;29(8):847-57.

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