Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005711)
Formula
SVG example
Demethylation
Reactant Dexchlorpheniramine maleate Product N-desmethyl-chlorpheniramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005710 Dexchlorpheniramine maleate Didesmethyl-chlorpheniramine Oxidation - Demethylation Dexchlorpheniramine maleate [1]
References
1 The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol. 2002 May;53(5):519-25.

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