Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005733)
Formula
SVG example
Glucuronidation
Reactant 4-Oxoretinoic acid Product 4-oxo-retinoyl glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [1], [2]
MR001259 4-hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Isotretinoin [3]
MR001255 4-oxo-13-cis-retinoic acid 4-Oxoretinoic acid Unclear Isotretinoin [3]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009628 4-Oxoretinoic acid 4-Oxoretinoic acid glucuronide Conjugation - Glucuronidation Tretinoin [5]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [3]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 Retinoic acid metabolism and mechanism of action: a review
3 DrugBank(Pharmacology-Metabolism)Isotretinoin
4 #NAME?
5 Clinical pharmacokinetics of tretinoin

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