Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001259)
Formula
SVG example
Oxidation
Reactant 4-hydroxyretinoic acid Product 4-Oxoretinoic acid
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [1]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [1], [2]
MR001254 All-trans-retinoic acid 4-hydroxyretinoic acid Oxidation - 4-Hydroxylation Isotretinoin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR001255 4-oxo-13-cis-retinoic acid 4-Oxoretinoic acid Unclear Isotretinoin [3]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009628 4-Oxoretinoic acid 4-Oxoretinoic acid glucuronide Conjugation - Glucuronidation Tretinoin [5]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [3]
MR005733 4-Oxoretinoic acid 4-oxo-retinoyl glucuronide Conjugation - Glucuronidation Beta carotene [4]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
3 DrugBank(Pharmacology-Metabolism)Isotretinoin
4 #NAME?
5 Clinical pharmacokinetics of tretinoin

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