Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005780)
Formula
SVG example
Oxidationn
Reactant Naloxegol oxalate Product Carboxymethyl-PEG6-Naloxol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005778 Naloxegol oxalate HO-PEG4-Naloxol Oxidation - Hydrolyzationn Naloxegol oxalate [1], [2]
MR005776 Naloxegol oxalate HO-PEG5-Naloxol Oxidation - Hydrolyzationn Naloxegol oxalate [1], [2]
MR005781 Naloxegol oxalate N-Dealkylated-mPEG7-Naloxol Oxidation - N-dealkylation Naloxegol oxalate [1]
References
1 Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects
2 Naloxegol: treatment for opioid-induced constipation in chronic non-cancer pain. Ann Pharmacother. 2015 Mar;49(3):360-5.

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