Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005778)
Formula Reactant Naloxegol oxalate Product HO-PEG4-Naloxol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005780 Naloxegol oxalate Carboxymethyl-PEG6-Naloxol Oxidation - Oxidationn Naloxegol oxalate [1], [2]
MR005776 Naloxegol oxalate HO-PEG5-Naloxol Oxidation - Hydrolyzationn Naloxegol oxalate [1], [2]
MR005781 Naloxegol oxalate N-Dealkylated-mPEG7-Naloxol Oxidation - N-dealkylation Naloxegol oxalate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005779 HO-PEG4-Naloxol Carboxymethyl-PEG3-Naloxol Oxidation - Oxidationn Naloxegol oxalate [1], [2]
References
1 Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects
2 Naloxegol: treatment for opioid-induced constipation in chronic non-cancer pain. Ann Pharmacother. 2015 Mar;49(3):360-5.

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