Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005935)
Formula
CYP2D6 ...
SVG example
Reactant CJ-11974 Product M17 CJ-12458
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005938 CJ-11974 CJ-11974 Ezlopitant Metabolite M14 Unclear CJ-11974 [1]
MR005924 CJ-11974 M16 CL12764 Unclear CJ-11974 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005936 M17 CJ-12458 CJ-11974 Ezlopitant Metabolite M12 Unclear CJ-11974 [1]
MR005937 M17 CJ-12458 CJ-11974 Ezlopitant Metabolite M7A Unclear CJ-11974 [1]
References
1 Metabolism, pharmacokinetics, and excretion of a nonpeptidic substance P receptor antagonist, ezlopitant, in normal healthy male volunteers: characterization of polar metabolites by chemical derivatization with dansyl chloride

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