General Information of This Metabolic Reaction (MR) (ID: MR005969)
Formula
CYP3A4 ...
SVG example
Reactant FCF-89 Product PNU-212684 4-hydroxy-N-(4-hydroxyphenyl)-N,1-dimethyl-2-oxoquinoline-3-carboxamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005970 FCF-89 4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide Unclear FCF-89 [1], [2]
MR005971 FCF-89 PNU-212679 N-Phenyl-N-methyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide Unclear FCF-89 [1], [2]
MR005966 FCF-89 PNU-213708 4,6-dihydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide Unclear FCF-89 [1], [2]
MR005968 FCF-89 PNU-213831 4,8-dihydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide Unclear FCF-89 [1], [2]
MR005967 FCF-89 PNU-214608 4,7-dihydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide Unclear FCF-89 [1], [2]
MR005972 FCF-89 R=glucuronic acid OH or sulphate Unclear FCF-89 [1], [2]
References
1 Absorption and disposition including enterohepatic circulation of (14C) roquinimex after oral administration to healthy volunteers
2 Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man. Xenobiotica. 2000 Sep;30(9):905-14.

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