Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006036)
Formula	Hydrolysis
	Reactant	Bendamustine	Product	Monohydroxy-bendamustine (bendamustine metabolite HP1)
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006038	Bendamustine	-hydroxybendamustine (Bendamustine metabolite M3)	Oxidation - Hydrolyzationn	Bendamustine	[1]
MR006040	Bendamustine	Beta-hydroxybendamustine	Unclear	Bendamustine	[2]
MR006039	Bendamustine	N-desmethyl-bendamustine (Bendamustine metabolite M4)	Oxidation - Dealkylation	Bendamustine	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006037	Monohydroxy-bendamustine (bendamustine metabolite HP1)	Dihydroxy-bendamustine (bendamustine metabolite HP2)	Hydrolysis - Hydrolysis	Bendamustine	[1]

References
1	Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54.
2	Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine

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