Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006039)
Formula
SVG example
Dealkylation
Reactant Bendamustine Product N-desmethyl-bendamustine (Bendamustine metabolite M4)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006038 Bendamustine -hydroxybendamustine (Bendamustine metabolite M3) Oxidation - Hydrolyzationn Bendamustine [1]
MR006040 Bendamustine Beta-hydroxybendamustine Unclear Bendamustine [2]
MR006036 Bendamustine Monohydroxy-bendamustine (bendamustine metabolite HP1) Hydrolysis - Hydrolysis Bendamustine [1]
References
1 Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54.
2 Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine

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