Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006095)
Formula
CYP2C9 ...
SVG example
N-demethylation
Reactant CC-223 Product O-desmethyl CC-223
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006098 CC-223 Imine CC-223 Unclear CC-223 [1]
MR006096 CC-223 Keto CC-223 Unclear CC-223 [1]
MR006097 CC-223 N-oxide CC-223 Oxidation - N-oxidation CC-223 [1]
References
1 Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70.

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