Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006098)
Formula
CYP3A4 ...
SVG example
Reactant CC-223 Product Imine CC-223
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006096 CC-223 Keto CC-223 Unclear CC-223 [1]
MR006097 CC-223 N-oxide CC-223 Oxidation - N-oxidation CC-223 [1]
MR006095 CC-223 O-desmethyl CC-223 Oxidation - N-demethylation CC-223 [1]
References
1 Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70.

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