Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006156)
Formula
SVG example
N-dealkylation
Reactant AC-1802 Product Desethylaprindine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006154 AC-1802 N-[3-(N,NDiethylamino)propyl]-N-phenyl-2-aminoindan-5-ol Oxidation - Aromatic hydroxylation AC-1802 [1]
MR006155 AC-1802 p-Hydroxyphenylaprindine Oxidation - Aromatic hydroxylation AC-1802 [1]
References
1 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.

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