Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006385)
Formula
SVG example
Glucuronidation
Reactant NSC-122758 Product Retinyl beta-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [1]
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR006382 NSC-122758 5,6-Epoxyretinoic acid Unclear NSC-122758 [1]
MR006381 NSC-122758 All-trans-18-Hydroxyretinoic acid Oxidation - Hydrolyzationn NSC-122758 [1], [2]
MR006384 NSC-122758 Retinoyl b-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.

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