Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006380)
Formula
CYP26C1 ...
SVG example
4-hydroxylation
Reactant NSC-122758 Product 4-Hydroxyretinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 26C1 (CYP26C1) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - 4-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR006382 NSC-122758 5,6-Epoxyretinoic acid Unclear NSC-122758 [1]
MR006381 NSC-122758 All-trans-18-Hydroxyretinoic acid Oxidation - Hydrolyzationn NSC-122758 [1], [2]
MR006384 NSC-122758 Retinoyl b-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
MR006385 NSC-122758 Retinyl beta-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [1], [3]
MR001254 All-trans-retinoic acid 4-hydroxyretinoic acid Oxidation - 4-Hydroxylation Isotretinoin [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [1], [5]
MR001259 4-hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Isotretinoin [4]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
4 DrugBank(Pharmacology-Metabolism)Isotretinoin
5 Retinoic acid metabolism and mechanism of action: a review

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.