Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006381)
Formula
CYP26C1 ...
SVG example
Hydrolyzationn
Reactant NSC-122758 Product All-trans-18-Hydroxyretinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 26C1 (CYP26C1) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [1]
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [1]
MR006382 NSC-122758 5,6-Epoxyretinoic acid Unclear NSC-122758 [1]
MR006384 NSC-122758 Retinoyl b-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
MR006385 NSC-122758 Retinyl beta-glucuronide Conjugation - Glucuronidation NSC-122758 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [1], [2], [3]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 Retinoic acid metabolism and mechanism of action: a review
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids

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