Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006395)
Formula
CYP2C19 ...
SVG example
Hydrolyzationn
Reactant PG-490 Product Hydroxytriptolide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006404 PG-490 Dehydrotriptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006401 PG-490 Dihydroxytriptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006406 PG-490 Hydrolyzed hydroxytriptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006408 PG-490 Hydrolyzed triptolide Oxidation - Hydrolyzationn PG-490 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006398 Hydroxytriptolide Hydroxytriptolide glucuronoside Conjugation - Conjugation PG-490 [1]
MR006399 Hydroxytriptolide Hydroxytriptolide glutathione Conjugation - Conjugation PG-490 [1]
MR006400 Hydroxytriptolide Hydroxytriptolide sulfate Conjugation - Conjugation PG-490 [1]
MR006396 Hydroxytriptolide Trihydroxytriptolide Unclear PG-490 [1]
References
1 Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.

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