Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006401)
Formula Reactant PG-490 Product Dihydroxytriptolide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006404 PG-490 Dehydrotriptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006406 PG-490 Hydrolyzed hydroxytriptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006408 PG-490 Hydrolyzed triptolide Oxidation - Hydrolyzationn PG-490 [1]
MR006395 PG-490 Hydroxytriptolide Oxidation - Hydrolyzationn PG-490 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006403 Dihydroxytriptolide Dehydrodihydroxytriptolide Conjugation - Conjugation PG-490 [1]
MR006402 Dihydroxytriptolide Dihydroxytriptolide sulfate Conjugation - Conjugation PG-490 [1]
References
1 Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.

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