Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006458)
Formula Reactant SCH-417690 Product O-Desmethylvicriviroc
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006463 SCH-417690 21,22-HDoHE Unclear SCH-417690 [1]
MR006462 SCH-417690 N,N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006461 SCH-417690 N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006459 SCH-417690 Vicriviroc hydroxylamine Unclear SCH-417690 [1]
MR006460 SCH-417690 Vicriviroc N-oxide Oxidation - N-oxidation SCH-417690 [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.