Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006463)
Formula
SVG example
Reactant SCH-417690 Product 21,22-HDoHE
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006462 SCH-417690 N,N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006461 SCH-417690 N-Desalkylvicriviroc Unclear SCH-417690 [1]
MR006458 SCH-417690 O-Desmethylvicriviroc Oxidation - O-demethylation SCH-417690 [1]
MR006459 SCH-417690 Vicriviroc hydroxylamine Unclear SCH-417690 [1]
MR006460 SCH-417690 Vicriviroc N-oxide Oxidation - N-oxidation SCH-417690 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006454 SC-411 21,22-HDoHE Unclear SC-411 [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):99-108.

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