Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006518)
Formula
SVG example
N-demethylation
Reactant Demethylcitalopram Product Didemethylcitalopram
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006517 Citalopram hydrobromide Demethylcitalopram Oxidation - N-demethylation Citalopram hydrobromide [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006521 Demethylcitalopram Citalopram propionaldehyde Oxidation - Oxidationn Citalopram hydrobromide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006519 Didemethylcitalopram Citalopram propionaldehyde Oxidation - Oxidationn Citalopram hydrobromide [2]
References
1 PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72.
2 Analytical methodologies for the enantiodetermination of citalopram and its metabolites

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