Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006614)
Formula Reactant Dolutegravir sodium Product Hydroxilated form of dolutegravir (M3)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006618 Dolutegravir sodium Defluorinated and gutathione conjugated form of dolutegravir (M4.1) Multi-steps Reaction - Glutathione conjugation; oxidative defluorination Dolutegravir sodium [1]
MR006619 Dolutegravir sodium Defluorinated and gutathione conjugated form of dolutegravir (M4.2) Multi-steps Reaction - Glutathione conjugation; oxidative defluorination Dolutegravir sodium [1]
MR006617 Dolutegravir sodium Ether glucuronide dolutegravir (M2) Conjugation - Glucuronidation Dolutegravir sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006615 Hydroxilated form of dolutegravir (M3) 2,4- difluorobenzaldehyde (M5 dolutegravir) Hydrolysis - Hydrolysis Dolutegravir sodium [1]
MR006616 Hydroxilated form of dolutegravir (M3) Hydrolized form of dolutegravir (M1) Hydrolysis - Hydrolysis Dolutegravir sodium [1]
References
1 Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans

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