Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006637)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Doravirine Product Doravirine M9 Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006644 Doravirine Doravirine Metabolite M11 Unclear Doravirine [1]
MR006646 Doravirine Doravirine Metabolite M15 Conjugation - N-acetyl cysteine conjugation Doravirine [1]
MR006642 Doravirine Doravirine Metabolite M18 Oxidation - Oxidationn Doravirine [1]
MR006643 Doravirine Doravirine Metabolite M19 Unclear Doravirine [1]
MR006640 Doravirine Doravirine Metabolite M5 Unclear Doravirine [1]
MR006645 Doravirine Doravirine Metabolite M8 Oxidation - Oxidationn Doravirine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006639 Doravirine M9 Metabolite Doravirine Metabolite M14 Unclear Doravirine [1]
MR006638 Doravirine M9 Metabolite Doravirine Metabolite M7 Conjugation - Glucuronidation Doravirine [1]
References
1 Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans. Xenobiotica. 2019 Apr;49(4):422-432.

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