Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006669)
Formula
SVG example
Demethylation
Reactant (E)-2-hydroxydoxepin Product (E)-2-hydroxy-N-desmethyldoxepin
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006668 Doxepin hydrochloride (E)-2-hydroxydoxepin Oxidation - Hydrolyzationn Doxepin hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006670 (E)-2-hydroxydoxepin Hydroxydoxepin glucuronide Conjugation - Glucuronidation Doxepin hydrochloride [2]
References
1 DrugBank(Pharmacology-Metabolism):Doxepin hydrochloride
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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