Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006668)
Formula
SVG example
Hydrolyzationn
Reactant Doxepin hydrochloride Product (E)-2-hydroxydoxepin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006666 Doxepin hydrochloride Doxepin N-oxide Oxidation - Oxidationn Doxepin hydrochloride [1]
MR006665 Doxepin hydrochloride Formaldehyde Oxidation - N-demethylation Doxepin hydrochloride [1]
MR006661 Doxepin hydrochloride N-desmethyldoxepin Oxidation - N-demethylation Doxepin hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006669 (E)-2-hydroxydoxepin (E)-2-hydroxy-N-desmethyldoxepin Oxidation - Demethylation Doxepin hydrochloride [1]
MR006670 (E)-2-hydroxydoxepin Hydroxydoxepin glucuronide Conjugation - Glucuronidation Doxepin hydrochloride [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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