Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006676)
Formula
NQO1 ...
SVG example
Reactant Doxorubicin Product Doxorubicin-semiquinone
Reactant Info Product Info
Metabolic Enzyme Quinone reductase 1 (NQO1) DME Info
Xanthine dehydrogenase/oxidase (XDH) DME Info
Nitric oxide synthase brain (NOS1) DME Info
Nitric oxide synthase inducible (NOS2) DME Info
Nitric oxide synthase endothelial (NOS3) DME Info
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006678 Doxorubicin 7-deoxydoxorubicinolone Unclear Doxorubicin [1]
MR006673 Doxorubicin Doxorubicine hydroxyaglycone Unclear Doxorubicin [2]
MR006675 Doxorubicin Doxorubicinol Unclear Doxorubicin [2]
MR006677 Doxorubicin Doxorubicinol deoxaglycone Unclear Doxorubicin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000094 Adriamycin Doxorubicin-semiquinone Unclear Adriamycin [3]
References
1 Pharmacokinetics and metabolism of doxorubicin after short-term infusions in lymphoma patients
2 PharmGKB:Doxorubicin
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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