Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006677)
Formula
POR ...
SVG example
Reactant Doxorubicin Product Doxorubicinol deoxaglycone
Reactant Info Product Info
Metabolic Enzyme NADPH-cytochrome P450 reductase (CPR) DME Info
Xanthine dehydrogenase/oxidase (XDH) DME Info
Quinone reductase 1 (NQO1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006678 Doxorubicin 7-deoxydoxorubicinolone Unclear Doxorubicin [1]
MR006676 Doxorubicin Doxorubicin-semiquinone Unclear Doxorubicin [2]
MR006673 Doxorubicin Doxorubicine hydroxyaglycone Unclear Doxorubicin [2]
MR006675 Doxorubicin Doxorubicinol Unclear Doxorubicin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000093 Adriamycin Doxorubicinol deoxaglycone Unclear Adriamycin [3]
MR009957 7-deoxydoxorubicinane 7-deoxydaxorubicinol Unclear - Unclear Epirubicin [4]
References
1 Pharmacokinetics and metabolism of doxorubicin after short-term infusions in lymphoma patients
2 PharmGKB:Doxorubicin
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 Comparative effects of paclitaxel and docetaxel on the metabolism and pharmacokinetics of epirubicin in breast cancer patients

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