Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006760)
Formula
SVG example
Amide Hydrolysis
Reactant Tocainide Product Tocainide metabolite M3
Reactant Info Product Info
Metabolic Type Hydrolysis - Amide Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006762 Tocainide Lactoxylidide Unclear Tocainide [1]
MR006757 Tocainide Tocainide Carbam Oyl 073-D-Glucuronide Unclear Tocainide [1]
MR006755 Tocainide Tocainide Carbaminic Acid Unclear Tocainide [2]
MR006759 Tocainide Tocainide metabolite M4 Unclear Tocainide [3]
MR006761 Tocainide Tocainide metabolite M5 Unclear Tocainide [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001551 Lidocaine 2,6-xylidine Unclear Lidocaine [4], [5], [6]
MR001545 Monoethylglycinexylidide 2,6-xylidine Hydrolysis - Hydrolysis Lidocaine [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001548 2,6-xylidine 4-hydroxy-2,6-xylidine Conjugation - Methylation Lidocaine [4]
References
1 On the kinetics and dynamics of tocainide and its metabolites
2 Tocainide kinetics and metabolism: effects of phenobarbital and substrates of glucuronyl transferase
3 Metabolism of tocainide in the rat
4 Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling J Pharm Sci. 1977 Aug;66(8):1180-90. doi: 10.1002/jps.2600660834.
5 An innovative nanoparticle-modified carbon paste sensor for ultrasensitive detection of lignocaine and its extremely carcinogenic metabolite residues in bovine food samples: Application of NEMI, ESA, AGREE, ComplexGAPI, and RGB12 algorithms. Food Chem. 2023 Jun 12;426:136579. doi: 10.1016/j.foodchem.2023.136579.
6 In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver. Toxicol In Vitro. 2021 Oct;76:105228. doi: 10.1016/j.tiv.2021.105228.
7 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.

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