Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001551)
Formula
SVG example
Reactant Lidocaine Product 2,6-xylidine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001555 Lidocaine . Unclear Lidocaine [1]
MR001552 Lidocaine 3-hydroxylidocaine Oxidation - Hydroxylation Lidocaine [2]
MR001550 Lidocaine Monoethylglycinexylidide Oxidation - N-De-Ethylation Lidocaine [1], [2]
MR001554 Lidocaine N-hydroxy-lidocaine Oxidation - Hydroxylation Lidocaine [2]
MR001553 Lidocaine NL-Ethyl-2-methyl-Nj-(2,6-dimethylphenyl)-4-imidazolidin Unclear Lidocaine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006760 Tocainide Tocainide metabolite M3 Hydrolysis - Amide Hydrolysis Tocainide [3]
MR001545 Monoethylglycinexylidide 2,6-xylidine Hydrolysis - Hydrolysis Lidocaine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001548 2,6-xylidine 4-hydroxy-2,6-xylidine Conjugation - Methylation Lidocaine [4]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.
3 Metabolism of tocainide in the rat
4 Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling J Pharm Sci. 1977 Aug;66(8):1180-90. doi: 10.1002/jps.2600660834.

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