Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001545)
Formula
SVG example
Hydrolysis
Reactant Monoethylglycinexylidide Product 2,6-xylidine
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001550 Lidocaine Monoethylglycinexylidide Oxidation - N-De-Ethylation Lidocaine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001547 Monoethylglycinexylidide 3-hydroxymonoethylglycinexylidide Unclear Lidocaine [2]
MR001546 Monoethylglycinexylidide Glycinexylidide Oxidation - Deamination Lidocaine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001551 Lidocaine 2,6-xylidine Unclear Lidocaine [3], [4], [5]
MR006760 Tocainide Tocainide metabolite M3 Hydrolysis - Amide Hydrolysis Tocainide [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001548 2,6-xylidine 4-hydroxy-2,6-xylidine Conjugation - Methylation Lidocaine [3]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.
3 Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling J Pharm Sci. 1977 Aug;66(8):1180-90. doi: 10.1002/jps.2600660834.
4 An innovative nanoparticle-modified carbon paste sensor for ultrasensitive detection of lignocaine and its extremely carcinogenic metabolite residues in bovine food samples: Application of NEMI, ESA, AGREE, ComplexGAPI, and RGB12 algorithms. Food Chem. 2023 Jun 12;426:136579. doi: 10.1016/j.foodchem.2023.136579.
5 In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver. Toxicol In Vitro. 2021 Oct;76:105228. doi: 10.1016/j.tiv.2021.105228.
6 Metabolism of tocainide in the rat

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.